Gene information
Official symbol ICAM1
Official full name intercellular adhesion molecule 1
Gene type protein-coding gene
Chromosome19p13.2
Alias symbolBB2; CD54
Gene familyCD molecules; Receptor ligands; Immunoglobulin like domain containing; Ig-like cell adhesion molecule family
Resources
Entrez Gene 3383
HGNC HGNC:5344
Ensembl ENSG00000090339
Vega OTTHUMG00000180403
UCSC uc002mnq.3
GO terms: 106 records
GO Description Category LogP Number of genes Detail
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001678 cellular glucose homeostasis GO Biological Processes -13.5994972 27 More
GO:0001772 immunological synapse GO Cellular Components -2.58671999 4 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001885 endothelial cell development GO Biological Processes -5.33490415 11 More
GO:0001910 regulation of leukocyte mediated cytotoxicity GO Biological Processes -7.82450130 11 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002285 lymphocyte activation involved in immune response GO Biological Processes -7.04246662 12 More
GO:0002286 T cell activation involved in immune response GO Biological Processes -5.33688125 8 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002691 regulation of cellular extravasation GO Biological Processes -7.79276545 8 More
GO:0002693 positive regulation of cellular extravasation GO Biological Processes -4.28303352 4 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO Biological Processes -3.60984508 9 More
GO:0007159 leukocyte cell-cell adhesion GO Biological Processes -16.8529519 16 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019062 virion attachment to host cell GO Biological Processes -3.59511628 3 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019882 antigen processing and presentation GO Biological Processes -2.12014641 5 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031341 regulation of cell killing GO Biological Processes -10.2641102 14 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0044406 adhesion of symbiont to host GO Biological Processes -4.89406977 4 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0044650 adhesion of symbiont to host cell GO Biological Processes -3.47400635 3 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045123 cellular extravasation GO Biological Processes -12.7826256 12 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0046813 receptor-mediated virion attachment to host cell GO Biological Processes -4.25319477 3 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060491 regulation of cell projection assembly GO Biological Processes -2.36338574 17 More
GO:0061028 establishment of endothelial barrier GO Biological Processes -4.39154198 8 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0071322 cellular response to carbohydrate stimulus GO Biological Processes -12.8816523 25 More
GO:0071326 cellular response to monosaccharide stimulus GO Biological Processes -13.2453179 24 More
GO:0071331 cellular response to hexose stimulus GO Biological Processes -12.5306046 23 More
GO:0071333 cellular response to glucose stimulus GO Biological Processes -12.7795214 23 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0072676 lymphocyte migration GO Biological Processes -7.69367801 10 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO Biological Processes -5.22391282 28 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0120032 regulation of plasma membrane bounded cell projection assembly GO Biological Processes -2.40785708 17 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:1900027 regulation of ruffle assembly GO Biological Processes -2.23601792 3 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -11.7829637 12 More
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -8.64891123 8 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904036 negative regulation of epithelial cell apoptotic process GO Biological Processes -12.0631217 12 More
GO:1904645 response to amyloid-beta GO Biological Processes -11.2505232 12 More
GO:1904646 cellular response to amyloid-beta GO Biological Processes -6.94782947 8 More
GO:1990823 response to leukemia inhibitory factor GO Biological Processes -3.54378087 13 More
GO:1990830 cellular response to leukemia inhibitory factor GO Biological Processes -3.58748665 13 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
GO:2000352 negative regulation of endothelial cell apoptotic process GO Biological Processes -10.8868003 10 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
KEGG pathways: 17 records
KEGG Description Category LogP Number of genes Detail
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04514 Cell adhesion molecules KEGG Pathway -5.33785320 11 More
hsa04650 Natural killer cell mediated cytotoxicity KEGG Pathway -3.46704202 8 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04670 Leukocyte transendothelial migration KEGG Pathway -6.49203386 11 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05166 Human T-cell leukemia virus 1 infection KEGG Pathway -5.08552863 13 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05416 Viral myocarditis KEGG Pathway -3.87607272 6 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
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Related drugs: 5 records
Related studies: 18 records
Molecular factor Omics type Application Objective MI type Reference
ICAM1 transcriptomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Zhuo LA et al. J Biol Chem. 2019
NM_000201.3:c.1405A>G genomics myocardial infarction[diagnosis] myocardial infarction Wang M et al. Zhonghua Liu Xing Bing Xue Za Zhi. 2005
intercellular adhesion molecule 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Kaikita K et al. Jpn Circ J. 1997
intercellular adhesion molecule 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Siminiak T et al. Int J Cardiol. 1997
intercellular adhesion molecule 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Li YH et al. Am J Cardiol. 1997
intercellular adhesion molecule 1 proteomics reperfusion arrhythmias[prognosis (bad)] acute myocardial infarction Murohara T et al. Crit Care Med. 2000
intercellular adhesion molecule 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Suzuki H et al. Eur J Clin Invest. 2008
intercellular adhesion molecule 1 proteomics recurrent myocardial infarction[prognosis (bad)] old myocardial infarction Marcinkowski M et al. Cardiol J. 2007
intercellular adhesion molecule 1 proteomics exercise[other] acute myocardial infarction Ribeiro F et al. Int J Sports Med. 2012
intercellular adhesion molecule 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Miller CS et al. J Dent Res. 2014
intercellular adhesion molecule 1 proteomics coenzyme Q10[treatment (pharmacotherapy)] acute myocardial infarction Mohseni M et al. Int J Prev Med. 2015
intercellular adhesion molecule 1 proteomics tirofiban[treatment (pharmacotherapy)] acute myocardial infarction Zhang Y et al. Exp Ther Med. 2018
intercellular adhesion molecule 1 proteomics good predictor heart failure[prognosis (bad)] acute ST elevation myocardial infarction Lino DOC et al. Braz J Med Biol Res. 2019
NM_000201.3:c.1405A>G genomics myocardial infarction[diagnosis] myocardial infarction Jiang H et al. Int J Cardiol. 2002
NM_000201.3:c.1405A>G genomics myocardial infarction[diagnosis] myocardial infarction Podgoreanu MV et al. Circulation. 2006
intercellular adhesion molecule 1 proteomics myocardial infarction[diagnosis] myocardial infarction Ridker PM et al. Lancet. 1998
intercellular adhesion molecule 1 proteomics coronary restenosis[prognosis (bad)] acute myocardial infarction Kamijikkoku S et al. Am Heart J. 1998
intercellular adhesion molecule 1 proteomics heart failure[prognosis (bad)] myocardial infarction Deleon-Pennell KY et al. ACS Omega. 2019
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